YES, FOR THE LOVE OF GOD YES! (I say this as a user who is over saturated on this issue, not as a mod).
(Puts on moderator hat)
As animuson points out, if it's just a signature, tagline, or whatever, REMOVE IT WITH EXTREME PREJUDICE.
There might be cases where the question is not just taglined, but truly core to SOPA, the blackout, and impacts.
If the question though relates to SOPA and/or the blackout today, it's probably more than likely that most of the instances are "too localized" or "off topic" (or will be at some point, regardless of the outcome).
If it's in reference to the blackout today, then I'd say it's almost absolutely "too localized". If it can be edited into a question dealing with outages in general, then I strongly recommend that you do, as removing something that can be transformed into good content is not helpful to Stack Overflow.
However, if the question has to do with dealing with outages in general and is using SOPA as an example, then I'd say that it's totally acceptable.
As an example, I posted this about the general impact of Wikpedia's approach to the blackout on on SEO over on Webmasters.SE which removed SOPA and the blackout from the core of the question (as it was an interesting SEO question in my mind, and not a conversation about SOPA and/or the blackout).