Removing a question has nothing to with Upvotes and Downvotes. Its still valid to close the question though it is Upvoted/Downvoted.
Check Deleted question link (Page Not Found Page) it states:
This question was removed from Stack Overflow for reasons of moderation. Please refer to the FAQ for possible explanations why a question might be removed
From the Deletion FAQ:
Questions that are extremely off topic, or of very low quality,
may be removed at the discretion of the community and moderators.
Over time, closed questions that are not useful as signpoints to other questions
may also be removed, as well as questions which have no significant activity over
a very long period after being asked.