When browsing the Stack Overlflow Careers site, the fonts look really bad in Chrome, while they look good in IE9. The zoom level in Chrome is 100%. Other Stack Exchange sites look good, it's just the Careers site. Running on Windows 7.
I can't repro this -- the http://careers.stackoverflow.com/ homepage looks fine to me in Chrome (current ver) on Windows 7
Font list is
I suspect you have Helv Neue installed. I've heard it can render badly on Windows, and Chrome in particular has not adopted the newer Firefox 4.0+ and IE9+ font rendering strategies on Windows...