This is a valid question because it is asking what is the most efficient Python data structure to store large amounts of bytearrays for in-memory random access.
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No it's not.
It is a poor question, a very poor question. It shows no research effort, lacks information and is highly subjective. We can not answer "what is the best way to do that", because we do not what the best is for the situation the OP is facing. Additionally, SE tries hard to be book full of knowledge to be usable by everyone at every moment. Such questions might be outdated in half a year, or plain out wrong if a users is facing a completely different situation with a similar problem.