An appreciative user of the Careers 2.0 service, I've failed a user design hurdle that I feel could be improved. Email interactions on the service are being sent to my Gmail account. I responded in-service to a compelling proposal from an employer. The next mail was from the HR team proposing dates for a follow-up. This, I mistakenly replied to from my Gmail account directly. A day passed and, when no reply arrived, I realized I'd replied to the firstname.lastname@example.org account which was suitably masked by Gmail's auto-naming feature.
Proposal: send automated responses to messages sent to the do-not-reply account pointing out the mailer's mistake (okay, I'll accept stupidity but I'll provide no apologies for being imperfect ;-)).
Update: I sent a mail directly to the DNR account from my Gmail account and have/did not receive a reply from it. The way Gmail presents the mails that I'm receiving, it curtails the mail with elipsis which, if I were to expand (I rarely do particularly in-thread) would have shown me the "reply to this message" guidance and link.