When choosing tags for a question, there are times when there are multiple tags available with the same meaning.
Ideally, those tags would be merged/removed, but unfortunately that is not the case. As an example, there is datatables (2515 questions), datatables.net (324 questions) and jquery-datatables (102 questions). All three of them have the same description. The first tag seems most ambiguous but has the highest number of followers. The last mentioned tag is least ambiguous but fewest number of followers. However, all three refer to the same technology.
My initial reaction tends to be wanting to use as many of those tags as possible to get the best exposure for the question.
What should be the approach and why? Look for number of question per tag? Number of followers? Use all? or doesn't make a difference?