On SO I have set up around 150 ignored tags. And this list is growing every day. But I still see new questions with tags I want to ignore that are very similar to my ignored ones.
For example I don't care about SQL. Not at all, not in any context. I'm just not interested.
So I have set up the following ignored tags: sql, sqlserver, sql-server, mysql, sqlite, sqlexpress, sqlserver2005, sqlserver2008, sql-server-2005, postgresql...
Then a new question might come up with the tag 'linq-to-sql' and I think "oh darn I'm gonna have to add that one too". It is really tedious to have to do this all the time (and it fuels my OCD :o)
I would like to add something like
*sql* as an ignored tag, and that should be the end of it.