I really, really doubt it. I've done the resume review thing. Any — absolutely any — activity I can find outside the doldrums of the resume is a major plus.
Jon Skeet (208,458) works for Google. Marc Gravell (160,544) works with Stack Overflow Inc. I can't imagine anyone spent a single second thinking "I wonder if these guys will get any work done if they are so awesome on that web site thing."
If I received a resume from the author of a book, I'm not going to say "How is this person going to work for me if they're out there writing book!" I'm going to find that book and see what good work they do. I can't imaging feeling any differently for a Stack Overflow user.
If the content is good, it's a net plus.