As I've mentioned elsewhere, I'd like to hear more from Jeff and Joel (and particularly a proper back-and-forth discussion between them) about the purpose of the reputation cap, and why/whether a time-sensitive approach is the most effective one. Even if that doesn't result in any changes, I think it would be an interesting discussion. That's just an example though - this question isn't meant to be about reputation!
What other StackOverflow-related topics would you like to hear discussed on the podcast? Do you particularly like the SO-related stuff, or are you more interested in general tech stuff? (Of course it's quite possible that J&J are sick of meta discussions, and any answers here will be pointless - but that's a different matter.)
Note that there's a separate question dealing with potential podcast guests, so it's probably best to keep the discussion off that topic here.