If I look at the home page (https://stackoverflow.com/), every single button on there except for two types works with JS off.
The first second is that the "x Votes; y answers;z views" mouse-over indicates they're links but clicking them does nothing. This one is less of an issue because the user can still click the question title, and they're only implied buttons anyway.
The second (and bigger) issue is the "Add" buttons next to "Favorite Tags" and "Ignored Tags". These are explicit buttons that don't do anything with JS off. There is no working JS substitute for them (the "tag subscriptions" link itself works, but the page it goes to doesn't work with JS off, but that's another bug report).