The status-norepro wiki states:
This tag indicates that the site developers were unable to recreate the behavior described in a bug report.
The not reproducible close reason states (emphasis mine):
The problem described here can no longer be reproduced. Changes to the system or to the circumstances affecting the asker have rendered it obsolete. If you encounter a similar problem, please post a new question.
Can we automatically close questions tagged status-norepro? Or, at the very least, when the community sees norepro questions, can we close them with this reason?
It may be better to simply stick the norepro questions into meta's CV review queue, too.
So, I've been VTCing many of the status-norepro questions, and every single one I've VTCed so far has been onholdified. That, honestly, is the strongest argument for this.