Catchphrases and concepts that spread from person to person are known as memes, which, courtesy the Internet, can now explode across the Earth like a highly contagious virus (hence "going viral"). As with their real-life counterparts, some infectious diseases are global (pandemic), while others are endemic to specific regions.
Stack Overflow, and now even more predominantly Meta Stack Exchange, have seen more than their fair share of these pathological social constructs spread through the user base. They are now ingrained units of our collective culture as SOpedians (a term which I hate, by the way).
Just as travelers' immune systems can be assaulted by new diseases in new places, new users are increasingly likely to be miffed by an ingrained meme and left sitting scratching their heads. I therefore propose that this space be used to document the memes endemic to Stack Exchange's culture.
Each meme should be listed in a separate answer and I hope that we as a community will be able to provide greater context to each one.
Please actually explain each meme in a way understandable to those not already in the know.