Every now and then, I encounter a First Post or Late Answer where I have no knowledge whatsoever concerning the topic at hand. Unless its obvious that the post is blatantly worthless (e.g.
"Have you found the answer yet?" or
"ssssszzzggggiclllll kjhk") I tend to skip these, but sometimes the situation is more complicated.
For instance, some questions can be answered (perhaps not particularly thoroughly, but answered nonetheless) in one sentence, while others may require absolutely gargantuan explanations in order to be complete. When I see a one-line question, my instinct is to request further explanation, but when I know nothing of the topic I don't even know if that's appropriate.
It's even worse for reviews of questions, when what seems like a perfectly good question to me could in fact be answered just by reading the wikipedia summary on the topic at hand, and what looks like a very poor question ends up receiving hundreds of upvotes because I didn't understand some subtlety of what was being asked due to my inexperience in the question's topic.
So in general which would be the better choice:
Use my best judgement when I can, and skip only when I am 100% lost as to what to do.
Immediately skip any post that falls outside the areas I am knowledgeable about
Thanks for everyone's input.