After deleting a comment while using Microsoft Edge browser, none of the action buttons will work (up/down vote, close, flag, etc.) until you refresh the page. I faced this in Travel.SE but I assume it's an SE wide issue.
I have tested this with Chrome/IE11 and I do not see the same behavior. I am using Windows 10 with November update.
Note: sometimes it just does not happen, most of the times it does.
Update
It's been 10 days with no reply from any SE team member, does that mean the bug does not exist or does it mean it's not a priority?