I've always been impressed with StackOverflow's cache: it seems to strike a perfect balance between snappiness and sensibility.
Which of the half-dozen* cache invalidation strategies promoted by Microsoft does StackOverflow use? I personally would love to hear a 2-3 sentence summary from a member of the team, and I imagine it would be instructive to a lot of people building sites on the MSFT stack.
*Okay, maybe I exaggerate.