Stack Overflow seems to be having some CSS issues right now. At first, it presented as CSS disappearing when refreshing in Firefox (though hitting Enter from the address bar seemed to restore it - I'm thinking that's a cache issue though). I loaded my blank Firefox profile and discovered CSS wasn't rendering on Stack Overflow at all (Meta seems fine; haven't checked other SE sites).
I've since checked the site in Chrome and Opera, and can repro in both.